Year : 2019  |  Volume : 27  |  Issue : 1  |  Page : 1-7

Evaluation of Ocular Pain During and After Intravitreal Injection of Antivascular Endothelial Growth Factors in South-West Nigeria

Department of Ophthalmology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria

Correspondence Address:
Dr. Judith G Akinwande
Department of Ophthalmology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njo.njo_22_18

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Aim: This article determines pain scores during and after intravitreal injections in black Africans so as to make evidence-based decisions in pain management. Settings and Design: This was a prospective cohort study conducted over 16 months following institutional ethical clearance on adults scheduled for intravitreal antivascular endothelial growth factor (anti-VEGF) therapy. Materials and Methods: Age, sex, indication for therapy, presence of diabetes mellitus, anti-VEGF agent, current dose of anti-VEGF taken, and quadrant of injection were recorded. Pain was measured with visual analog scale during the procedure and 15 min, 30 min, 1 h, and 3 h after procedure. Pain intensity was classified into no pain, mild, moderate, and severe. Data were analyzed using Statistical Package for the Social Sciences version 22.0, P-value below 0.05 was considered statistically significant. Results: A total of 49 eyes of 49 patients with male-to-female ratio of 1.2:1 and mean age of 66.61 ± 11.24 years were studied. Most common indication for anti-VEGF was diabetic retinopathy (17, 34.7%) and most patients (34, 69.4%) received bevacizumab. The mean pain score during injection was 36.33 ± 23.25; this progressively decreased with time to 0.20 ± 1.42 by 3 h postinjection (P < 0.001). Six (12.2%) patients experienced no pain at all during the injection, whereas mean pain score was significantly higher in those who had bevacizumab injections (P = 0.031) and diabetes (P = 0.013). Pain was mainly mild in severity during the injection and female patients tended to have more severe pains. Conclusion: Pain during intravitreal anti-VEGF in black Africans is mild, and it resolves within 3 h of the injection.

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